Active Pharmaceutical Ingredients (APIs)
Calcium Polysytyrene Sulfonate BP/JP – Doshion P-548
Calcium polystyrene Sulfonate is a Cation Exchange Resin prepared in the Calcium phase. Each gram of Resin has a theoretical in vitro exchange capacity of about 1.3 to 2 mmol of Potassium bound will be less than this. Calcium Polystyrene Sulfonate acts by a cumulative process throughout the GI Tract, removing Potassium ions which are carried away in the feces. The typical dosage amounts are 15-16 gms per day.
Sodium Polystyrene Sulfonate USP – Doshion P-504
The kidney usually excrete Potassium ions from the body. In case of severe Hyperkalamia, patients can be given a Cation Resin to bind with the Potassium ion. Sodium Polystayrene Sulfonate remains in the intestine, where it adsorbs Potassium ions and forms a complex of Resin and excretes the Potassium ions through feces.
Cholestyramine Resin USP/ EP – Doshion P-550
Cholestyramine Resin USP adsorbs and combines with the bile acids in the intestine to form an insoluble complex which is excreted in the feces. This results in a partial removal of bile acids from the enterohepatic circulation by preventing their absorption.
The increased fecal loss of bile acids due to Cholestyramine Resin leads to an increased oxidation of cholesterol to bile acids, a decrease in beta lipoprotein or low density lipoprotein plasma levels and a decrease in the serum cholestrol levels. The typical dosage amounts are 8-24 gms per day.